SummaryThere is still proportionally little agreement about nearly all topics according to arthritis; the character and progress of pain and fatigue in arthritis itself as well as their relations with problematic moods and several resources/burdens, as personal and network characteristics. The literature review found that there is no direct attribution between pain and affective problems. On the other hand symptoms were of great impact for psychiatric illnesses but mediated also between inflammation and stress. It is well documented in this report that the degree of fatigue as well as pain can predict depression. Few studies could detect that a past episode of depression could have the effect that pain at baseline was higher than in people without a depression history. On the other hand social distress had a strengthening effect on this relation. Other studies wherein psychosocial factors had impact on the relation between RA symptomatic and mood problems are correlated and some researchers detected that helplessness not only affect depression but also increases pain perception and mediate the relation between depression and pain and other even found that that internal attributions as helplessness enforce pain perception and depression. These findings are well documented in Covic 2006; Zautra (2007; Frantom, 2006; Chaney, 2004)Our interviews indicates that arthritis could develop sence of fatigue an depression or ,anxiety which could lead to social distress. However, social support is important to comfort patent and mediate the impact of loneliness or social isolation. Thus, good social support is particularly important for coping with symptoms as fatigue, pain and emotions in rheumatoid arthritis whereby accretive social isolation and problematic social support worsen the experience of disease symptoms. Evdence on this was recorded in Krol, et.al, 1993, Morrison & Bennet, 2006; Riemsma, et.al, 2000, and Szotek, 2010.